Role of Ceramide in the Barrier Function of the Stratum Corneum, Implications for the Pathogenesis of Atopic Dermatitis
نویسندگان
چکیده
Abbreviations: TEWL: Transepidermal Water Loss; AD: Atopic Dermatitis; SC: Stratum Corneum; HC: Healthy Control; PiCl: Picryl Chloride; MA: House Dust Mite Antigens; SM: Sphingomyelin; GCer: Glucosylceramide; BGCase: Beta-Glucocerebrosidase; SMase: Acid Sphingomyelinase; CBE: Conduritol B Epoxide; DSP: Despiramine Hydrochloride; PDMP: 1-Phenyl-2-Decanoylamino-3-Morpholino-1Propanol; SPT: Serine Palmitoyl Transferase; CDase: Acid Ceramidase; SPC: Sphingosylphosphorylcholine; GSP: Glucosylsphingosine; HIRU: Mucopolysaccharide; CER: Synthetic Pseudo-Ceramide
منابع مشابه
Difference in ceramide composition between "dry" and "normal" skin in patients with atopic dermatitis.
Sir, Many patients with atopic dermatitis have widespread dry skin, which has a disturbed water barrier function (1). Stratum corneum lipids play an important role here. Recently, various authors have reported that dry skin in people with atopic dermatitis shows a marked reduction in ceramides (2, 3). We measured the ceramides in dry and normal skin of patients with atopic dermatitis and compar...
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Ceramides (CERs) are integral parts of the intercellular lipid lamellae of the stratum corneum (SC), which is responsible for the barrier function of the skin. Many skin diseases such as atopic dermatitis and psoriasis are associated with the depletion or disturbance of the level of CERs in the SC. Administration of an exogenous novel dimeric ceramide (dCER) deep into the SC may help to stabili...
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Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J Invest Dermatol 1991; 96: 523 ^ 526. 3. Di Nardo A,Wertz P, Gianetti A, Seidenari S. Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol (Stockh) 1998; 78: 27 ^ 30. 4. Hani¢n JM, Rajka G. Diagnostic features of atopic dermatitis. Act...
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The function of the horny layer of the skin as a barrier is to protect the underlying tissues from infection, dryness, and mechanical stress. Disruption of this function results in increased transepidermal water loss (TEWL) and is associated with conditions like atopic dermatitis and other chronic skin diseases. Moisturizers have been shown to improve these conditions through restoration of the...
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